Skeletal muscle mitochondrial-methylation-neurotransmitter crosstalk: a novel synergistic model of betaine, tyrosine, and Cordyceps(cordyceps) for exercise performance in older adults, individuals with metabolic disorders, and healthy populations.

한국어 요약

2026년 발표된 「Skeletal muscle mitochondrial-methylation-neurotransmitter crosstalk: a novel synergistic model of betaine, tyrosine, and Cordyceps for exercise performance in older adults, individuals with metabolic disorders, and healthy populations.」은(는) Cordyceps militaris (동충하초) 및 코디세핀 관련 동물·세포 실험(전임상)입니다. 아래는 원문 초록을 바탕으로 한 중립적 요약이며, 제품 효능·효과를 의미하지 않습니다.

초록 요지

Athletic performance and exercise adaptation are influenced by intricately coordinated interactions among mitochondrial bioenergetics, methylation-dependent metabolic pathways, and the regulation of central neurotransmitters. The potential of Cordyceps-based supplementation to enhance mitochondrial ATP production, optimize oxygen utilization, and improve fatigue resistance has been extensively studied. Nevertheless, the exploration of its integration with complementary metabolic modulators remains inadequately addressed. This review introduces an innovative systems-level model that synthesizes Cordyceps with betaine and tyrosine, aiming to target both peripheral and central determinants of athletic performance. Betaine acts as a methyl donor and osmolyte, facilitating creatine synthesis, enhancing cellular hydration, and promoting metabolic resilience, thereby improving muscle power output and fostering adaptations in body composition. Tyrosine, serving as a precursor for catecholamines, significantly influences dopaminergic and noradrenergic signaling, with the potential to mitigate central fatigue and enhance cognitive endurance in the presence of physiological stress. We propose a comprehensive integrative framework of mitochondrial-methylation-neurotransmitter interactions to elucidate how these agents may collectively augment ATP efficiency, redox equilibrium, neuromuscular performance, and recovery processes. Notably, this model may possess translational implications not solely for healthy athletes but also for elderly populations and individuals experiencing metabolic dysfunction, wherein compromised mitochondrial activity and neurotransmitter signaling play a pivotal role in diminished exercise capacity. Subsequent mechanistic and clinical investigations are essential to substantiate this multi-faceted supplementation approach aimed at precision performance enhancement.

전문가 메모

• 연구 수준: 동물/세포 실험 · 동물·세포 실험(전임상)
• 대상: Cordyceps militaris (동충하초) / unclear
• 제품 연관성: partial
• 해석 주의: 전임상(동물·세포) 결과는 인간 섭취·담금주 맥락으로 직접 확장하기 어렵습니다.
• 인사이트: 배양·생산·기초 메커니즘 연구로 읽는 것이 적절합니다. 소비자 효능 주장 근거로 사용할 수 없습니다.

출처 · 원문

• 제목: Skeletal muscle mitochondrial-methylation-neurotransmitter crosstalk: a novel synergistic model of betaine, tyrosine, and Cordyceps for exercise performance in older adults, individuals with metabolic disorders, and healthy populations.
• 저자: Xu C 외 3명
• 연도: 2026
• DOI: 10.3389/fnut.2026.1812286
• PMID: 42682565
• 링크: https://europepmc.org/article/MED/42682565

원문 초록 (English)

Summary — Athletic performance and exercise adaptation are influenced by intricately coordinated interactions among mitochondrial bioenergetics, methylation-dependent metabolic pathways, and the regulation of central neurotransmitters. The potential of Cordyceps-based supplementation to enhance mitochondrial ATP production, optimize oxygen utilization, and improve fatigue resistance has been extensively studied. Nevertheless, the exploration of its integration with complementary metabolic modulators remains inadequately addressed. This review introduces an innovative systems-level model that synthesizes Cordyceps with betaine and tyrosine, aiming to target both peripheral and central determinants of athletic performance. Betaine acts as a methyl donor and osmolyte, facilitating creatine synthesis, enhancing cellular hydration, and promoting metabolic resilience, thereby improving muscle power output and fostering adaptations in body composition. Tyrosine, serving as a precursor for catecholamines, significantly influences dopaminergic and noradrenergic signaling, with the potential to mitigate central fatigue and enhance cognitive endurance in the presence of physiological stress. We propose a comprehensive integrative framework of mitochondrial-methylation-neurotransmitter interactions to elucidate how these agents may collectively augment ATP efficiency, redox equilibrium, neuromuscular performance, and recovery processes. Notably, this model may possess translational implications not solely for healthy athletes but also for elderly populations and individuals experiencing metabolic dysfunction, wherein compromised mitochondrial activity and neurotransmitter signaling play a pivotal role in diminished exercise capacity. Subsequent mechanistic and clinical investigations are essential to substantiate this multi-faceted supplementation approach aimed at precision performance enhancement.

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