코디세핀 항산화 효과가 결합되어 과도한 운동으로 인한 피로를 개선합니다.

한국어 요약

2025년 발표된 「Cordycepin combined with antioxidant effects improves fatigue caused by excessive exercise.」은(는) Cordyceps militaris (동충하초) 및 코디세핀 관련 동물·세포 실험(전임상)입니다. 아래는 원문 초록을 바탕으로 한 중립적 요약이며, 제품 효능·효과를 의미하지 않습니다.

초록 요지

Excessive exercise can lead to physical fatigue and disruption of the antioxidant system, resulting in neurological damage and cognitive decline. Cordycepin, the main component of Cordyceps militaris, has anti-inflammatory, antioxidant and neuroprotective effects. In this study, the anti-fatigue effect and potential mechanism of action of cordycepin were investigated using a forced exercise mouse model. The results showed that oral administration of cordycepin enhanced exercise endurance, increased liver and muscle glycogen content, and simultaneously decreased serum levels of lactic acid, lactate dehydrogenase, creatine kinase, and blood urea nitrogen (p < 0.05). In addition, cordycepin had antioxidant effects, increasing superoxide dismutase activity and decreasing serum malondialdehyde (MDA) levels (p < 0.01). In vitro experiments further demonstrated the antioxidant and anti-fatigue effects of cordycepin. Behavioral tests showed that the learning and memory ability of mice in the excessive exercise model group decreased to 40% compared with the control group. Cordycepin alleviated the learning and memory deficits in the over-exercised mice, significantly reduced the levels of fatigue metabolites and oxidative stress in vivo (p < 0.05), and altered the levels of neurotransmitters levels (p < 0.05). Furthermore, cordycepin modulated Keap1/Nrf2/HO-1-mediated oxidative stress and enhanced BDNF levels (p < 0.05). These findings suggest that cordycepin can alleviate excessive exercise-induced fatigue by modulating the Keap1/Nrf2/HO-1 signaling pathway and BDNF expression, providing strong supporting evidence for the development of cordycepin-functional foods or anti-fatigue drugs.

전문가 메모

• 연구 수준: 동물/세포 실험 · 동물·세포 실험(전임상)
• 대상: Cordyceps militaris (동충하초) / cordycepin
• 제품 연관성: direct
• 해석 주의: 전임상(동물·세포) 결과는 인간 섭취·담금주 맥락으로 직접 확장하기 어렵습니다.
• 인사이트: 배양·생산·기초 메커니즘 연구로 읽는 것이 적절합니다. 소비자 효능 주장 근거로 사용할 수 없습니다.

출처 · 원문

• 제목: Cordycepin combined with antioxidant effects improves fatigue caused by excessive exercise.
• 저자: Chunfang Cheng 외 11명
• 연도: 2025
• 저널: Scientific reports
• DOI: 10.1002/cbf.3903
• PMID: 40059099
• 링크: https://pubmed.ncbi.nlm.nih.gov/40059099/

원문 초록 (English)

Summary — Excessive exercise can lead to physical fatigue and disruption of the antioxidant system, resulting in neurological damage and cognitive decline. Cordycepin, the main component of Cordyceps militaris, has anti-inflammatory, antioxidant and neuroprotective effects. In this study, the anti-fatigue effect and potential mechanism of action of cordycepin were investigated using a forced exercise mouse model. The results showed that oral administration of cordycepin enhanced exercise endurance, increased liver and muscle glycogen content, and simultaneously decreased serum levels of lactic acid, lactate dehydrogenase, creatine kinase, and blood urea nitrogen (p < 0.05). In addition, cordycepin had antioxidant effects, increasing superoxide dismutase activity and decreasing serum malondialdehyde (MDA) levels (p < 0.01). In vitro experiments further demonstrated the antioxidant and anti-fatigue effects of cordycepin. Behavioral tests showed that the learning and memory ability of mice in the excessive exercise model group decreased to 40% compared with the control group. Cordycepin alleviated the learning and memory deficits in the over-exercised mice, significantly reduced the levels of fatigue metabolites and oxidative stress in vivo (p < 0.05), and altered the levels of neurotransmitters levels (p < 0.05). Furthermore, cordycepin modulated Keap1/Nrf2/HO-1-mediated oxidative stress and enhanced BDNF levels (p < 0.05). These findings suggest that cordycepin can alleviate excessive exercise-induced fatigue by modulating the Keap1/Nrf2/HO-1 signaling pathway and BDNF expression, providing strong supporting evidence for the development of cordycepin-functional foods or anti-fatigue drugs.

---

본 페이지는 학술 문헌을 연구·교육 목적으로 요약·정리한 자료입니다. 질병의 예방·치료·진단과 무관하며, 제왕충초 담금주의 효능·효과를 주장하지 않습니다. ‘효능 관련 논문’은 연구자들이 다루는 생리활성·기능성 주제를 뜻하며, 제품 광고 문구가 아닙니다. 원문과 상이한 해석이 있을 수 있으며, 인용 시 반드시 원문을 확인하세요.